• Article (title, authors, journal, year and pages):  Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression – Chen N-H.-Pharmacological Reports 2010 – 62 – 150-163
  • Plant (scientific name of the main plant):  Ganoderma lucidum
  • WP4 reference member:  Prof. Laura Maria Garcia Bermejo
  • Plant/s used (if a phytocomplex from one or more plants are used):
  • Formula used (if a phytocomplex from a formula is used):
  • Purified molecules used (if single compounds are used): ganoderic acid T
  • Disease/s:  cancer
  • molecular target/s and/or mechanisms investigated:  inhibition of proliferation, inhibition of adhesion to ECM, induction of homotypic aggregation, inhibition of cell migration, down-regulation of the expression of matrix metalloproteinase-9

    (MMP-9), inducible nitric oxide synthase (iNOS), and urokinase-type plasminogen activator (uPA).

  • General quality score (mean ± SD):  article not meeting inclusion criteria for evaluation
  • Relevance score for TCM research (mean ± SD):  article not meeting inclusion criteria for evaluation
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